Compare commits
10 Commits
v2.0.3
...
f8f8636cc3
| Author | SHA1 | Date | |
|---|---|---|---|
| f8f8636cc3 | |||
| 13b522f6a0 | |||
| 05cd2d79df | |||
| bc52a250a4 | |||
| 830c0a7586 | |||
| c94a7902c0 | |||
| 8ccb45748d | |||
| 63a375995c | |||
| 2351faf2d7 | |||
| a446bbd923 |
@@ -1,9 +1,10 @@
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.PHONY: build clean test
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.PHONY: build clean test dev-init
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build: clean
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build: clean
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@echo "======================== Building Binary ======================="
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@echo "======================== Building Binary ======================="
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minify wfa.js > dist/wfa.js
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mkdir -p dist
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GOOS=js GOARCH=wasm CGO_ENABLED=0 tinygo build -panic=trap -no-debug -opt=2 -target=wasm -o dist/wfa.wasm .
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cp wfa.js dist/wfa.js
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GOOS=js GOARCH=wasm CGO_ENABLED=0 tinygo build -panic=trap -no-debug -opt=s -target=wasm -o dist/wfa.wasm .
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clean:
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clean:
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@echo "======================== Cleaning Project ======================"
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@echo "======================== Cleaning Project ======================"
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@@ -24,3 +25,6 @@ test:
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@rm -f mem.prof
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@rm -f mem.prof
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@rm -f test.test
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@rm -f test.test
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dev-init:
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go get -t wfa/test
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@@ -1,6 +1,6 @@
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# Using WFA-JS
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# Using WFA-JS
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Download `wfa.js` and `wfa.wasm`from [releases](https://git.tronnet.net/tronnet/WFA-JS/releases) to your project. Add to your script:
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Download `wfa.js` and `wfa.wasm`from [releases](https://git.tronnet.net/alu/WFA-JS/releases) to your project. Add to your script:
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```
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```
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import wfa from "./wfa.js"
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import wfa from "./wfa.js"
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@@ -1,15 +1,15 @@
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module wfa
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module wfa
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go 1.23.2
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go 1.26.4
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require (
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require (
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github.com/schollz/progressbar/v3 v3.17.1
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github.com/schollz/progressbar/v3 v3.19.1
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golang.org/x/exp v0.0.0-20241108190413-2d47ceb2692f
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golang.org/x/exp v0.0.0-20260611194520-c48552f49976
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)
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)
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require (
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require (
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github.com/mitchellh/colorstring v0.0.0-20190213212951-d06e56a500db // indirect
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github.com/mitchellh/colorstring v0.0.0-20190213212951-d06e56a500db // indirect
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github.com/rivo/uniseg v0.4.7 // indirect
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github.com/rivo/uniseg v0.4.7 // indirect
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golang.org/x/sys v0.27.0 // indirect
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golang.org/x/sys v0.46.0 // indirect
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golang.org/x/term v0.26.0 // indirect
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golang.org/x/term v0.44.0 // indirect
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)
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)
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+31
@@ -0,0 +1,31 @@
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<!DOCTYPE html>
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<html>
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<head>
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<script src="wfa.js" type="module"></script>
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<script type="module">
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import wfaInit from "./wfa.js";
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wfaInit("dist/wfa.wasm");
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window.addEventListener("DOMContentLoaded", () => {
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document.querySelector("#submit").addEventListener("click", () => {
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a = document.querySelector("#a").value
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b = document.querySelector("#b").value
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const penalties = {
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m: 0,
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x: 1,
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o: 0,
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e: 1
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};
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const { score, CIGAR } = global.wfa.wfAlign(a, b, penalties, true);
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const alignment = global.wfa.DecodeCIGAR(CIGAR);
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document.querySelector("#result").innerText = `${score}, ${CIGAR}, ${alignment}`;
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})
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});
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</script>
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</head>
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<body>
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<label>A: </label><input id="a">
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<label>B: </label><input id="b">
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<button id="submit">Submit</button>
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<p><span>Result: </span><span id="result"></span></p>
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</body>
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</html>
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@@ -7,8 +7,8 @@ import (
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func main() {
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func main() {
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c := make(chan bool)
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c := make(chan bool)
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js.Global().Set("wfAlign", js.FuncOf(wfAlign))
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js.Global().Get("wfa").Set("wfAlign", js.FuncOf(wfAlign))
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js.Global().Set("DecodeCIGAR", js.FuncOf(DecodeCIGAR))
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js.Global().Get("wfa").Set("DecodeCIGAR", js.FuncOf(DecodeCIGAR))
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<-c
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<-c
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}
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}
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+10
-17
@@ -6,38 +6,31 @@ type PositiveSlice[T any] struct {
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defaultValue T
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defaultValue T
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}
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}
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func (a *PositiveSlice[T]) TranslateIndex(idx int) int {
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return idx
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}
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func (a *PositiveSlice[T]) Valid(idx int) bool {
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func (a *PositiveSlice[T]) Valid(idx int) bool {
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actualIdx := a.TranslateIndex(idx)
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return 0 <= idx && idx < len(a.valid) && a.valid[idx]
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return 0 <= actualIdx && actualIdx < len(a.valid) && a.valid[actualIdx]
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}
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}
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func (a *PositiveSlice[T]) Get(idx int) T {
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func (a *PositiveSlice[T]) Get(idx int) T {
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actualIdx := a.TranslateIndex(idx)
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if 0 <= idx && idx < len(a.valid) && a.valid[idx] { // idx is in the slice
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if 0 <= actualIdx && actualIdx < len(a.valid) && a.valid[actualIdx] { // idx is in the slice
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return a.data[idx]
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return a.data[actualIdx]
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} else { // idx is out of the slice
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} else { // idx is out of the slice
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return a.defaultValue
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return a.defaultValue
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}
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}
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}
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}
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func (a *PositiveSlice[T]) Set(idx int, value T) {
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func (a *PositiveSlice[T]) Set(idx int, value T) {
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actualIdx := a.TranslateIndex(idx)
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if idx >= len(a.valid) { // idx is outside the slice
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if actualIdx < 0 || actualIdx >= len(a.valid) { // idx is outside the slice
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// expand data array to 2*idx
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// expand data array to actualIdx
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newData := make([]T, 2*idx+1)
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newData := make([]T, 2*actualIdx+1)
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copy(newData, a.data)
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copy(newData, a.data)
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a.data = newData
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a.data = newData
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// expand valid array to actualIdx
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// expand valid array to 2*idx
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newValid := make([]bool, 2*actualIdx+1)
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newValid := make([]bool, 2*idx+1)
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copy(newValid, a.valid)
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copy(newValid, a.valid)
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a.valid = newValid
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a.valid = newValid
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}
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}
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|
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a.data[actualIdx] = value
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a.data[idx] = value
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a.valid[actualIdx] = true
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a.valid[idx] = true
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}
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}
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+17
-19
@@ -1,5 +1,9 @@
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package wfa
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package wfa
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type Integer interface {
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~int | ~int8 | ~int16 | ~int32 | ~int64 | ~uint | ~uint8 | ~uint16 | ~uint32 | ~uint64 | ~uintptr
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}
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|
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type Result struct {
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type Result struct {
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Score int
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Score int
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CIGAR string
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CIGAR string
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@@ -40,25 +44,22 @@ func UnpackWavefrontLoHi(lohi WavefrontLoHi) (int, int) {
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return loBM, hiBM
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return loBM, hiBM
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}
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}
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// bitpacked wavefront values with 1 valid bit, 3 traceback bits, and 28 bits for the diag distance
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// bitpacked wavefront values with 1 valid bit, 3 traceback bits, and 60 bits for the diag distance
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// technically this restricts to alignments with less than 268 million characters but that should be sufficient for most cases
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type WavefrontValue uint64
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type WavefrontValue uint32
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// TODO: add 64 bit packed value in case more than 268 million characters are needed
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|
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// PackWavefrontValue: packs a diag value and traceback into a WavefrontValue
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// PackWavefrontValue: packs a diag value and traceback into a WavefrontValue
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func PackWavefrontValue(value uint32, traceback Traceback) WavefrontValue {
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func PackWavefrontValue(value uint64, traceback Traceback) WavefrontValue {
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validBM := uint32(0x8000_0000)
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validBM := uint64(0x8000_0000_0000_0000)
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tracebackBM := uint32(traceback&0x0000_0007) << 28
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tracebackBM := uint64(traceback&0x0000_0007) << 60
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valueBM := value & 0x0FFF_FFFF
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valueBM := uint64(value) & 0x0FFF_FFFF_FFFF_FFFF
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return WavefrontValue(validBM | tracebackBM | valueBM)
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return WavefrontValue(validBM | tracebackBM | valueBM)
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}
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}
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// UnpackWavefrontValue: opens a WavefrontValue into a valid bool, diag value and traceback
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// UnpackWavefrontValue: opens a WavefrontValue into a valid bool, diag value and traceback
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func UnpackWavefrontValue(wfv WavefrontValue) (bool, uint32, Traceback) {
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func UnpackWavefrontValue(wfv WavefrontValue) (bool, uint64, Traceback) {
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validBM := wfv&0x8000_0000 != 0
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validBM := wfv&0x8000_0000_0000_0000 != 0
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tracebackBM := uint8(wfv & 0x7000_0000 >> 28)
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tracebackBM := uint8(wfv & 0x7000_0000_0000_0000 >> 60)
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valueBM := uint32(wfv & 0x0FFF_FFFF)
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valueBM := uint64(wfv & 0x0000_0000_FFFF_FFFF)
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return validBM, valueBM, Traceback(tracebackBM)
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return validBM, valueBM, Traceback(tracebackBM)
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}
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}
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|
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@@ -71,12 +72,9 @@ type Wavefront struct { // since wavefronts store diag distance, they should nev
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// NewWavefront: returns a new wavefront with size accomodating lo and hi (inclusive)
|
// NewWavefront: returns a new wavefront with size accomodating lo and hi (inclusive)
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func NewWavefront(lo int, hi int) *Wavefront {
|
func NewWavefront(lo int, hi int) *Wavefront {
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a := &Wavefront{}
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a := &Wavefront{}
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|
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a.lohi = PackWavefrontLoHi(lo, hi)
|
a.lohi = PackWavefrontLoHi(lo, hi)
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size := hi - lo
|
size := hi - lo
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|
a.data = make([]WavefrontValue, size+1)
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newData := make([]WavefrontValue, size+1)
|
|
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a.data = newData
|
|
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|
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return a
|
return a
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}
|
}
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@@ -134,12 +132,12 @@ func NewWavefrontComponent() *WavefrontComponent {
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}
|
}
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|
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// GetVal: get value for wavefront=score, diag=k => returns ok, value, traceback
|
// GetVal: get value for wavefront=score, diag=k => returns ok, value, traceback
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||||||
func (w *WavefrontComponent) GetVal(score int, k int) (bool, uint32, Traceback) {
|
func (w *WavefrontComponent) GetVal(score int, k int) (bool, uint64, Traceback) {
|
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return UnpackWavefrontValue(w.W.Get(score).Get(k))
|
return UnpackWavefrontValue(w.W.Get(score).Get(k))
|
||||||
}
|
}
|
||||||
|
|
||||||
// SetVal: set value, traceback for wavefront=score, diag=k
|
// SetVal: set value, traceback for wavefront=score, diag=k
|
||||||
func (w *WavefrontComponent) SetVal(score int, k int, val uint32, tb Traceback) {
|
func (w *WavefrontComponent) SetVal(score int, k int, val uint64, tb Traceback) {
|
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w.W.Get(score).Set(k, PackWavefrontValue(val, tb))
|
w.W.Get(score).Set(k, PackWavefrontValue(val, tb))
|
||||||
}
|
}
|
||||||
|
|
||||||
|
|||||||
+41
-41
@@ -1,23 +1,18 @@
|
|||||||
package wfa
|
package wfa
|
||||||
|
|
||||||
import (
|
const MaxInt = int(^uint(0) >> 1)
|
||||||
"math"
|
const MinInt = -MaxInt - 1
|
||||||
"strings"
|
|
||||||
|
|
||||||
"golang.org/x/exp/constraints"
|
|
||||||
)
|
|
||||||
|
|
||||||
|
// convert an unsigned into to string
|
||||||
func UIntToString(num uint) string { // num assumed to be positive
|
func UIntToString(num uint) string { // num assumed to be positive
|
||||||
var builder strings.Builder
|
str := []rune{}
|
||||||
|
|
||||||
for num > 0 {
|
for num > 0 {
|
||||||
digit := num % 10
|
digit := num % 10
|
||||||
builder.WriteRune(rune('0' + digit))
|
str = append(str, rune('0'+digit))
|
||||||
num /= 10
|
num /= 10
|
||||||
}
|
}
|
||||||
|
|
||||||
// Reverse the string as we built it in reverse order
|
|
||||||
str := []rune(builder.String())
|
|
||||||
for i, j := 0, len(str)-1; i < j; i, j = i+1, j-1 {
|
for i, j := 0, len(str)-1; i < j; i, j = i+1, j-1 {
|
||||||
str[i], str[j] = str[j], str[i]
|
str[i], str[j] = str[j], str[i]
|
||||||
}
|
}
|
||||||
@@ -25,8 +20,9 @@ func UIntToString(num uint) string { // num assumed to be positive
|
|||||||
return string(str)
|
return string(str)
|
||||||
}
|
}
|
||||||
|
|
||||||
|
// decode runlength encoded string such as CIGARs
|
||||||
func RunLengthDecode(encoded string) string {
|
func RunLengthDecode(encoded string) string {
|
||||||
decoded := strings.Builder{}
|
decoded := []rune{}
|
||||||
length := len(encoded)
|
length := len(encoded)
|
||||||
i := 0
|
i := 0
|
||||||
|
|
||||||
@@ -42,45 +38,30 @@ func RunLengthDecode(encoded string) string {
|
|||||||
if i < length {
|
if i < length {
|
||||||
char := encoded[i]
|
char := encoded[i]
|
||||||
for j := 0; j < runLength; j++ {
|
for j := 0; j < runLength; j++ {
|
||||||
decoded.WriteByte(char)
|
decoded = append(decoded, rune(char))
|
||||||
}
|
}
|
||||||
i++ // Move past the character
|
i++ // Move past the character
|
||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
return decoded.String()
|
return string(decoded)
|
||||||
}
|
}
|
||||||
|
|
||||||
func SafeMin[T constraints.Integer](values []T, idx int) T {
|
// given the min index, return the item in values at that index
|
||||||
|
func SafeMin[T Integer](values []T, idx int) T {
|
||||||
return values[idx]
|
return values[idx]
|
||||||
}
|
}
|
||||||
|
|
||||||
func SafeMax[T constraints.Integer](values []T, idx int) T {
|
// given the max index, return the item in values at that index
|
||||||
|
func SafeMax[T Integer](values []T, idx int) T {
|
||||||
return values[idx]
|
return values[idx]
|
||||||
}
|
}
|
||||||
|
|
||||||
func SafeArgMax[T constraints.Integer](valids []bool, values []T) (bool, int) {
|
// given array of values and corresponding array of valid flags, find the min of value which is valid or return false if there does not exist any
|
||||||
hasValid := false
|
func SafeArgMin[T Integer](valids []bool, values []T) (bool, int) {
|
||||||
maxIndex := 0
|
|
||||||
maxValue := math.MinInt
|
|
||||||
for i := 0; i < len(valids); i++ {
|
|
||||||
if valids[i] && int(values[i]) > maxValue {
|
|
||||||
hasValid = true
|
|
||||||
maxIndex = i
|
|
||||||
maxValue = int(values[i])
|
|
||||||
}
|
|
||||||
}
|
|
||||||
if hasValid {
|
|
||||||
return true, maxIndex
|
|
||||||
} else {
|
|
||||||
return false, 0
|
|
||||||
}
|
|
||||||
}
|
|
||||||
|
|
||||||
func SafeArgMin[T constraints.Integer](valids []bool, values []T) (bool, int) {
|
|
||||||
hasValid := false
|
hasValid := false
|
||||||
minIndex := 0
|
minIndex := 0
|
||||||
minValue := math.MaxInt
|
minValue := MaxInt
|
||||||
for i := 0; i < len(valids); i++ {
|
for i := 0; i < len(valids); i++ {
|
||||||
if valids[i] && int(values[i]) < minValue {
|
if valids[i] && int(values[i]) < minValue {
|
||||||
hasValid = true
|
hasValid = true
|
||||||
@@ -95,6 +76,22 @@ func SafeArgMin[T constraints.Integer](valids []bool, values []T) (bool, int) {
|
|||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
|
// given array of values and corresponding array of valid flags, find the max of value which is valid or return false if there does not exist any
|
||||||
|
func SafeArgMax[T Integer](valids []bool, values []T) (bool, int) {
|
||||||
|
hasValid := false
|
||||||
|
maxIndex := 0
|
||||||
|
maxValue := MinInt
|
||||||
|
for i := range valids {
|
||||||
|
if valids[i] && int(values[i]) > maxValue {
|
||||||
|
hasValid = true
|
||||||
|
maxIndex = i
|
||||||
|
maxValue = int(values[i])
|
||||||
|
}
|
||||||
|
}
|
||||||
|
return hasValid, maxIndex
|
||||||
|
}
|
||||||
|
|
||||||
|
// set the lext lo and hi bounds for wavefronts M, I, D
|
||||||
func NextLoHi(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent, score int, penalties Penalty) (int, int) {
|
func NextLoHi(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent, score int, penalties Penalty) (int, int) {
|
||||||
x := penalties.X
|
x := penalties.X
|
||||||
o := penalties.O
|
o := penalties.O
|
||||||
@@ -125,6 +122,7 @@ func NextLoHi(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponen
|
|||||||
return lo, hi
|
return lo, hi
|
||||||
}
|
}
|
||||||
|
|
||||||
|
// set the traceback and diag value for the next I wavefront
|
||||||
func NextI(M *WavefrontComponent, I *WavefrontComponent, score int, k int, penalties Penalty) {
|
func NextI(M *WavefrontComponent, I *WavefrontComponent, score int, k int, penalties Penalty) {
|
||||||
o := penalties.O
|
o := penalties.O
|
||||||
e := penalties.E
|
e := penalties.E
|
||||||
@@ -132,13 +130,14 @@ func NextI(M *WavefrontComponent, I *WavefrontComponent, score int, k int, penal
|
|||||||
a_ok, a, _ := M.GetVal(score-o-e, k-1)
|
a_ok, a, _ := M.GetVal(score-o-e, k-1)
|
||||||
b_ok, b, _ := I.GetVal(score-e, k-1)
|
b_ok, b, _ := I.GetVal(score-e, k-1)
|
||||||
|
|
||||||
ok, nextITraceback := SafeArgMax([]bool{a_ok, b_ok}, []uint32{a, b})
|
ok, nextITraceback := SafeArgMax([]bool{a_ok, b_ok}, []uint64{a, b})
|
||||||
nextIVal := SafeMax([]uint32{a, b}, nextITraceback) + 1 // important that the +1 is here
|
nextIVal := SafeMax([]uint64{a, b}, nextITraceback) + 1 // important that the +1 is here
|
||||||
if ok {
|
if ok {
|
||||||
I.SetVal(score, k, nextIVal, []Traceback{OpenIns, ExtdIns}[nextITraceback])
|
I.SetVal(score, k, nextIVal, []Traceback{OpenIns, ExtdIns}[nextITraceback])
|
||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
|
// set the traceback and diag value for the next D wavefront
|
||||||
func NextD(M *WavefrontComponent, D *WavefrontComponent, score int, k int, penalties Penalty) {
|
func NextD(M *WavefrontComponent, D *WavefrontComponent, score int, k int, penalties Penalty) {
|
||||||
o := penalties.O
|
o := penalties.O
|
||||||
e := penalties.E
|
e := penalties.E
|
||||||
@@ -146,13 +145,14 @@ func NextD(M *WavefrontComponent, D *WavefrontComponent, score int, k int, penal
|
|||||||
a_ok, a, _ := M.GetVal(score-o-e, k+1)
|
a_ok, a, _ := M.GetVal(score-o-e, k+1)
|
||||||
b_ok, b, _ := D.GetVal(score-e, k+1)
|
b_ok, b, _ := D.GetVal(score-e, k+1)
|
||||||
|
|
||||||
ok, nextDTraceback := SafeArgMax([]bool{a_ok, b_ok}, []uint32{a, b})
|
ok, nextDTraceback := SafeArgMax([]bool{a_ok, b_ok}, []uint64{a, b})
|
||||||
nextDVal := SafeMax([]uint32{a, b}, nextDTraceback)
|
nextDVal := SafeMax([]uint64{a, b}, nextDTraceback)
|
||||||
if ok {
|
if ok {
|
||||||
D.SetVal(score, k, nextDVal, []Traceback{OpenDel, ExtdDel}[nextDTraceback])
|
D.SetVal(score, k, nextDVal, []Traceback{OpenDel, ExtdDel}[nextDTraceback])
|
||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
|
// set the traceback and diag value for the next M wavefront
|
||||||
func NextM(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent, score int, k int, penalties Penalty) {
|
func NextM(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent, score int, k int, penalties Penalty) {
|
||||||
x := penalties.X
|
x := penalties.X
|
||||||
|
|
||||||
@@ -161,8 +161,8 @@ func NextM(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent,
|
|||||||
b_ok, b, _ := I.GetVal(score, k)
|
b_ok, b, _ := I.GetVal(score, k)
|
||||||
c_ok, c, _ := D.GetVal(score, k)
|
c_ok, c, _ := D.GetVal(score, k)
|
||||||
|
|
||||||
ok, nextMTraceback := SafeArgMax([]bool{a_ok, b_ok, c_ok}, []uint32{a, b, c})
|
ok, nextMTraceback := SafeArgMax([]bool{a_ok, b_ok, c_ok}, []uint64{a, b, c})
|
||||||
nextMVal := SafeMax([]uint32{a, b, c}, nextMTraceback)
|
nextMVal := SafeMax([]uint64{a, b, c}, nextMTraceback)
|
||||||
if ok {
|
if ok {
|
||||||
M.SetVal(score, k, nextMVal, []Traceback{Sub, Ins, Del}[nextMTraceback])
|
M.SetVal(score, k, nextMVal, []Traceback{Sub, Ins, Del}[nextMTraceback])
|
||||||
}
|
}
|
||||||
|
|||||||
+21
-23
@@ -1,14 +1,11 @@
|
|||||||
package wfa
|
package wfa
|
||||||
|
|
||||||
import (
|
// WFAlign takes strings s1, s2, penalties, and returns the score and CIGAR if doCIGAR is true
|
||||||
"strings"
|
|
||||||
)
|
|
||||||
|
|
||||||
func WFAlign(s1 string, s2 string, penalties Penalty, doCIGAR bool) Result {
|
func WFAlign(s1 string, s2 string, penalties Penalty, doCIGAR bool) Result {
|
||||||
n := len(s1)
|
n := len(s1)
|
||||||
m := len(s2)
|
m := len(s2)
|
||||||
A_k := m - n
|
A_k := m - n // diagonal where both sequences end
|
||||||
A_offset := uint32(m)
|
A_offset := uint64(m) // offset along a_k diagonal corresponding to end
|
||||||
score := 0
|
score := 0
|
||||||
M := NewWavefrontComponent()
|
M := NewWavefrontComponent()
|
||||||
M.SetLoHi(0, 0, 0)
|
M.SetLoHi(0, 0, 0)
|
||||||
@@ -19,7 +16,7 @@ func WFAlign(s1 string, s2 string, penalties Penalty, doCIGAR bool) Result {
|
|||||||
for {
|
for {
|
||||||
WFExtend(M, s1, n, s2, m, score)
|
WFExtend(M, s1, n, s2, m, score)
|
||||||
ok, val, _ := M.GetVal(score, A_k)
|
ok, val, _ := M.GetVal(score, A_k)
|
||||||
if ok && val >= A_offset {
|
if ok && val >= A_offset { // exit when M_(s,a_k) >= A_offset, ie the wavefront has reached the end
|
||||||
break
|
break
|
||||||
}
|
}
|
||||||
score = score + 1
|
score = score + 1
|
||||||
@@ -27,7 +24,7 @@ func WFAlign(s1 string, s2 string, penalties Penalty, doCIGAR bool) Result {
|
|||||||
}
|
}
|
||||||
|
|
||||||
CIGAR := ""
|
CIGAR := ""
|
||||||
if doCIGAR {
|
if doCIGAR { // if doCIGAR, then perform backtrace, otherwise just return the score
|
||||||
CIGAR = WFBacktrace(M, I, D, score, penalties, A_k, A_offset, s1, s2)
|
CIGAR = WFBacktrace(M, I, D, score, penalties, A_k, A_offset, s1, s2)
|
||||||
}
|
}
|
||||||
|
|
||||||
@@ -39,23 +36,24 @@ func WFAlign(s1 string, s2 string, penalties Penalty, doCIGAR bool) Result {
|
|||||||
|
|
||||||
func WFExtend(M *WavefrontComponent, s1 string, n int, s2 string, m int, score int) {
|
func WFExtend(M *WavefrontComponent, s1 string, n int, s2 string, m int, score int) {
|
||||||
_, lo, hi := M.GetLoHi(score)
|
_, lo, hi := M.GetLoHi(score)
|
||||||
for k := lo; k <= hi; k++ {
|
for k := lo; k <= hi; k++ { // for each diagonal in current wavefront
|
||||||
// v = M[score][k] - k
|
// v = M[score][k] - k
|
||||||
// h = M[score][k]
|
// h = M[score][k]
|
||||||
ok, hu, _ := M.GetVal(score, k)
|
ok, uh, tb := M.GetVal(score, k)
|
||||||
h := int(hu)
|
// exit early if M_(s,l) is invalid
|
||||||
v := h - k
|
|
||||||
|
|
||||||
// exit early if v or h are invalid
|
|
||||||
if !ok {
|
if !ok {
|
||||||
continue
|
continue
|
||||||
}
|
}
|
||||||
for v < n && h < m && s1[v] == s2[h] {
|
h := int(uh)
|
||||||
_, val, tb := M.GetVal(score, k)
|
v := h - k
|
||||||
M.SetVal(score, k, val+1, tb)
|
// in the paper, we do v++, h++, M_(s,k)++
|
||||||
|
// however, note that h = M_(s,k) so instead we just do v++, h++ and set M_(s,k) at the end
|
||||||
|
// this saves a some memory reads and writes
|
||||||
|
for v < n && h < m && s1[v] == s2[h] { // extend diagonal for the next set of matches
|
||||||
v++
|
v++
|
||||||
h++
|
h++
|
||||||
}
|
}
|
||||||
|
M.SetVal(score, k, uint64(h), tb)
|
||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
@@ -63,14 +61,14 @@ func WFNext(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent,
|
|||||||
// get this score's lo, hi
|
// get this score's lo, hi
|
||||||
lo, hi := NextLoHi(M, I, D, score, penalties)
|
lo, hi := NextLoHi(M, I, D, score, penalties)
|
||||||
|
|
||||||
for k := lo; k <= hi; k++ {
|
for k := lo; k <= hi; k++ { // for each diagonal, extend the matrices for the next wavefronts
|
||||||
NextI(M, I, score, k, penalties)
|
NextI(M, I, score, k, penalties)
|
||||||
NextD(M, D, score, k, penalties)
|
NextD(M, D, score, k, penalties)
|
||||||
NextM(M, I, D, score, k, penalties)
|
NextM(M, I, D, score, k, penalties)
|
||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
func WFBacktrace(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent, score int, penalties Penalty, A_k int, A_offset uint32, s1 string, s2 string) string {
|
func WFBacktrace(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontComponent, score int, penalties Penalty, A_k int, A_offset uint64, s1 string, s2 string) string {
|
||||||
x := penalties.X
|
x := penalties.X
|
||||||
o := penalties.O
|
o := penalties.O
|
||||||
e := penalties.E
|
e := penalties.E
|
||||||
@@ -187,11 +185,11 @@ func WFBacktrace(M *WavefrontComponent, I *WavefrontComponent, D *WavefrontCompo
|
|||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
CIGAR := strings.Builder{}
|
CIGAR := ""
|
||||||
for i := len(Ops) - 1; i > 0; i-- {
|
for i := len(Ops) - 1; i > 0; i-- {
|
||||||
CIGAR.WriteString(UIntToString(Counts[i]))
|
CIGAR += UIntToString(Counts[i])
|
||||||
CIGAR.WriteRune(Ops[i])
|
CIGAR += string(Ops[i])
|
||||||
}
|
}
|
||||||
|
|
||||||
return CIGAR.String()
|
return CIGAR
|
||||||
}
|
}
|
||||||
|
|||||||
+2
-2
@@ -36,8 +36,8 @@ func randRange[T constraints.Integer](min, max int) T {
|
|||||||
|
|
||||||
func TestWavefrontPacking(t *testing.T) {
|
func TestWavefrontPacking(t *testing.T) {
|
||||||
for range 1000 {
|
for range 1000 {
|
||||||
val := randRange[uint32](0, 1000)
|
val := randRange[uint64](0, 1000)
|
||||||
tb := wfa.Traceback(randRange[uint32](0, 7))
|
tb := wfa.Traceback(randRange[uint64](0, 7))
|
||||||
v := wfa.PackWavefrontValue(val, tb)
|
v := wfa.PackWavefrontValue(val, tb)
|
||||||
|
|
||||||
valid, gotVal, gotTB := wfa.UnpackWavefrontValue(v)
|
valid, gotVal, gotTB := wfa.UnpackWavefrontValue(v)
|
||||||
|
|||||||
@@ -1,5 +1,3 @@
|
|||||||
// wasm_exec.js from tinygo
|
|
||||||
|
|
||||||
// Copyright 2018 The Go Authors. All rights reserved.
|
// Copyright 2018 The Go Authors. All rights reserved.
|
||||||
// Use of this source code is governed by a BSD-style
|
// Use of this source code is governed by a BSD-style
|
||||||
// license that can be found in the LICENSE file.
|
// license that can be found in the LICENSE file.
|
||||||
@@ -134,6 +132,7 @@
|
|||||||
const decoder = new TextDecoder("utf-8");
|
const decoder = new TextDecoder("utf-8");
|
||||||
let reinterpretBuf = new DataView(new ArrayBuffer(8));
|
let reinterpretBuf = new DataView(new ArrayBuffer(8));
|
||||||
var logLine = [];
|
var logLine = [];
|
||||||
|
const wasmExit = {}; // thrown to exit via proc_exit (not an error)
|
||||||
|
|
||||||
global.Go = class {
|
global.Go = class {
|
||||||
constructor() {
|
constructor() {
|
||||||
@@ -272,14 +271,11 @@
|
|||||||
fd_close: () => 0, // dummy
|
fd_close: () => 0, // dummy
|
||||||
fd_fdstat_get: () => 0, // dummy
|
fd_fdstat_get: () => 0, // dummy
|
||||||
fd_seek: () => 0, // dummy
|
fd_seek: () => 0, // dummy
|
||||||
"proc_exit": (code) => {
|
proc_exit: (code) => {
|
||||||
if (global.process) {
|
this.exited = true;
|
||||||
// Node.js
|
this.exitCode = code;
|
||||||
process.exit(code);
|
this._resolveExitPromise();
|
||||||
} else {
|
throw wasmExit;
|
||||||
// Can't exit in a browser.
|
|
||||||
throw 'trying to exit with code ' + code;
|
|
||||||
}
|
|
||||||
},
|
},
|
||||||
random_get: (bufPtr, bufLen) => {
|
random_get: (bufPtr, bufLen) => {
|
||||||
crypto.getRandomValues(loadSlice(bufPtr, bufLen));
|
crypto.getRandomValues(loadSlice(bufPtr, bufLen));
|
||||||
@@ -287,31 +283,45 @@
|
|||||||
},
|
},
|
||||||
},
|
},
|
||||||
gojs: {
|
gojs: {
|
||||||
// func ticks() float64
|
// func ticks() int64
|
||||||
"runtime.ticks": () => {
|
"runtime.ticks": () => {
|
||||||
return timeOrigin + performance.now();
|
return BigInt((timeOrigin + performance.now()) * 1e6);
|
||||||
},
|
},
|
||||||
|
|
||||||
// func sleepTicks(timeout float64)
|
// func sleepTicks(timeout int64)
|
||||||
"runtime.sleepTicks": (timeout) => {
|
"runtime.sleepTicks": (timeout) => {
|
||||||
// Do not sleep, only reactivate scheduler after the given timeout.
|
// Do not sleep, only reactivate scheduler after the given timeout.
|
||||||
setTimeout(this._inst.exports.go_scheduler, timeout);
|
setTimeout(() => {
|
||||||
|
if (this.exited) return;
|
||||||
|
try {
|
||||||
|
this._inst.exports.go_scheduler();
|
||||||
|
} catch (e) {
|
||||||
|
if (e !== wasmExit) throw e;
|
||||||
|
}
|
||||||
|
}, Number(timeout)/1e6);
|
||||||
},
|
},
|
||||||
|
|
||||||
// func finalizeRef(v ref)
|
// func finalizeRef(v ref)
|
||||||
"syscall/js.finalizeRef": (v_ref) => {
|
"syscall/js.finalizeRef": (v_ref) => {
|
||||||
const id = mem().getUint32(unboxValue(v_ref), true);
|
// Note: TinyGo does not support finalizers so this is only called
|
||||||
this._goRefCounts[id]--;
|
// for one specific case, by js.go:jsString. and can/might leak memory.
|
||||||
if (this._goRefCounts[id] === 0) {
|
const id = v_ref & 0xffffffffn;
|
||||||
const v = this._values[id];
|
if (this._goRefCounts?.[id] !== undefined) {
|
||||||
this._values[id] = null;
|
this._goRefCounts[id]--;
|
||||||
this._ids.delete(v);
|
if (this._goRefCounts[id] === 0) {
|
||||||
this._idPool.push(id);
|
const v = this._values[id];
|
||||||
|
this._values[id] = null;
|
||||||
|
this._ids.delete(v);
|
||||||
|
this._idPool.push(id);
|
||||||
|
}
|
||||||
|
} else {
|
||||||
|
console.error("syscall/js.finalizeRef: unknown id", id);
|
||||||
}
|
}
|
||||||
},
|
},
|
||||||
|
|
||||||
// func stringVal(value string) ref
|
// func stringVal(value string) ref
|
||||||
"syscall/js.stringVal": (value_ptr, value_len) => {
|
"syscall/js.stringVal": (value_ptr, value_len) => {
|
||||||
|
value_ptr >>>= 0;
|
||||||
const s = loadString(value_ptr, value_len);
|
const s = loadString(value_ptr, value_len);
|
||||||
return boxValue(s);
|
return boxValue(s);
|
||||||
},
|
},
|
||||||
@@ -472,21 +482,25 @@
|
|||||||
this._ids = new Map(); // mapping from JS values to reference ids
|
this._ids = new Map(); // mapping from JS values to reference ids
|
||||||
this._idPool = []; // unused ids that have been garbage collected
|
this._idPool = []; // unused ids that have been garbage collected
|
||||||
this.exited = false; // whether the Go program has exited
|
this.exited = false; // whether the Go program has exited
|
||||||
|
this.exitCode = 0;
|
||||||
|
|
||||||
while (true) {
|
if (this._inst.exports._start) {
|
||||||
const callbackPromise = new Promise((resolve) => {
|
let exitPromise = new Promise((resolve, reject) => {
|
||||||
this._resolveCallbackPromise = () => {
|
this._resolveExitPromise = resolve;
|
||||||
if (this.exited) {
|
|
||||||
throw new Error("bad callback: Go program has already exited");
|
|
||||||
}
|
|
||||||
setTimeout(resolve, 0); // make sure it is asynchronous
|
|
||||||
};
|
|
||||||
});
|
});
|
||||||
this._inst.exports._start();
|
|
||||||
if (this.exited) {
|
// Run program, but catch the wasmExit exception that's thrown
|
||||||
break;
|
// to return back here.
|
||||||
|
try {
|
||||||
|
this._inst.exports._start();
|
||||||
|
} catch (e) {
|
||||||
|
if (e !== wasmExit) throw e;
|
||||||
}
|
}
|
||||||
await callbackPromise;
|
|
||||||
|
await exitPromise;
|
||||||
|
return this.exitCode;
|
||||||
|
} else {
|
||||||
|
this._inst.exports._initialize();
|
||||||
}
|
}
|
||||||
}
|
}
|
||||||
|
|
||||||
@@ -494,7 +508,11 @@
|
|||||||
if (this.exited) {
|
if (this.exited) {
|
||||||
throw new Error("Go program has already exited");
|
throw new Error("Go program has already exited");
|
||||||
}
|
}
|
||||||
this._inst.exports.resume();
|
try {
|
||||||
|
this._inst.exports.resume();
|
||||||
|
} catch (e) {
|
||||||
|
if (e !== wasmExit) throw e;
|
||||||
|
}
|
||||||
if (this.exited) {
|
if (this.exited) {
|
||||||
this._resolveExitPromise();
|
this._resolveExitPromise();
|
||||||
}
|
}
|
||||||
@@ -524,8 +542,9 @@
|
|||||||
}
|
}
|
||||||
|
|
||||||
const go = new Go();
|
const go = new Go();
|
||||||
WebAssembly.instantiate(fs.readFileSync(process.argv[2]), go.importObject).then((result) => {
|
WebAssembly.instantiate(fs.readFileSync(process.argv[2]), go.importObject).then(async (result) => {
|
||||||
return go.run(result.instance);
|
let exitCode = await go.run(result.instance);
|
||||||
|
process.exit(exitCode);
|
||||||
}).catch((err) => {
|
}).catch((err) => {
|
||||||
console.error(err);
|
console.error(err);
|
||||||
process.exit(1);
|
process.exit(1);
|
||||||
@@ -537,22 +556,22 @@
|
|||||||
export default function init (path) {
|
export default function init (path) {
|
||||||
return new Promise ((res) => {
|
return new Promise ((res) => {
|
||||||
const go = new Go();
|
const go = new Go();
|
||||||
var wasm;
|
const run = (obj) => {
|
||||||
|
const wasm = obj.instance;
|
||||||
|
global.wfa = wasm
|
||||||
|
go.run(wasm);
|
||||||
|
res()
|
||||||
|
}
|
||||||
if ('instantiateStreaming' in WebAssembly) {
|
if ('instantiateStreaming' in WebAssembly) {
|
||||||
WebAssembly.instantiateStreaming(fetch(path), go.importObject).then(function (obj) {
|
WebAssembly.instantiateStreaming(fetch(path), go.importObject).then(function (obj) {
|
||||||
wasm = obj.instance;
|
run(obj)
|
||||||
go.run(wasm);
|
|
||||||
res()
|
|
||||||
})
|
})
|
||||||
} else {
|
} else {
|
||||||
fetch(path).then(resp =>
|
fetch(path).then(resp =>
|
||||||
resp.arrayBuffer()
|
resp.arrayBuffer()
|
||||||
).then(bytes =>
|
).then(bytes =>
|
||||||
WebAssembly.instantiate(bytes, go.importObject).then(function (obj) {
|
WebAssembly.instantiate(bytes, go.importObject).then(function (obj) {
|
||||||
wasm = obj.instance;
|
run(obj)
|
||||||
go.run(wasm);
|
|
||||||
res()
|
|
||||||
})
|
})
|
||||||
)
|
)
|
||||||
}
|
}
|
||||||
|
|||||||
Reference in New Issue
Block a user